On the other side, WGBS was applied to perform global enhancer methylation profiling of three HCC tumors, in which aberrant enhancer hypomethylation of C/EBPβ was discovered and validated as causally linked to C/EBPβ overexpression, thereby contributing to hepatocarcinogenesis through global transcriptional reprogramming (25). Here, CEBPB is linked to hepatocellular carcinoma.