In the present study, we identified abundant hypomethylated enhancer-associated activated HCC-related genes such as MUC13 (119), SPINK1 (105), and KIF2C (97), plus hypermethylated enhancer-associated repression of known HCC suppressors like DUSP1 (80) and ADI1 (83). This evidence concerns the gene ADI1 and hepatocellular carcinoma.