Moreover, the set of high-confidence DMR-DEGs contains a high proportion of previously experimentally validated HCC driver genes, many other cancer-relevant genes, and some uncharacterized genes with considerable biological function, for instance, cell division cycle 20 (CDC20), a critical coactivator of the cellular division essential complex—anaphase-promoting complex/cyclosome (APC/C), whose overexpression has been associated with the development of a multitude of cancers such as those of the prostate (79) and liver (78). The gene discussed is CDC20; the disease is cancer.