GRHL2 and hepatocellular carcinoma: On the other hand, 75 genes repressed by promoter hypermethylation failed to be enriched in any pathways, possibly because of the small number of genes, but many of them, such as ST8SIA6-AS1 (49) and GRHL2 (50), were reported to play a suppressor role in multiple cancers including HCC (Table 2).