Although a large number of studies have focused on the association of TYMS with carcinogenesis, prognosis, chemotherapy reaction in colorectal cancer (13, 14), ovarian cancer (10), pancreatic cancer (11), cervical cancer (12), and breast cancer (9), few studies focused on the role of TYMS in metastatic HCC patients. This evidence concerns the gene TYMS and familial pancreatic carcinoma.