For example, BsAB AMG330 binds CD33 antigen on AML cells as well as MDSCs cells and CD3ɛ on T-cells. In an open-label Phase 1 study (Clinicaltrial.gov identifier: NCT#02520427), AMG330 was given at doses ranging from 0.5–720 μg/d in the manner of continuous IV infusion among 55 patients with R/R AML (NCT02520427). This evidence concerns the gene CD33 and acute myeloid leukemia.