Tumor cells derived granulocyte macrophage-colony stimulating factor (GM-CSF) induces fatty acid transport protein 2 (FATP2) expression in MDSCs by activation of STAT3 pathway, which confers the function of intratumoral PMN-MDSCs by the upregulation of arachidonic acid metabolism and the production of ROS (136). This evidence concerns the gene STAT3 and neoplasm.