Among these 19 candidate circRNAs (circ_0008594, circ_0004293, circ_0003832, circ_0055521, circ_0039914, circ_0007610, circ_0039522, circ_0010146, circ_0052320, circ_0008351, circ_0000014, circ_0008545, circ_0006892, circ_0008884, circ_0000508, circ_0001666, circ_0047398, circ_0083377, circ_0000664), only circ_0001666 is previously reported to regulate NSCLC progression via miR-330-5p/HMGA2 signaling, while the other 18 circRNAs are not reported in NSCLC (39). Here, HMGA2 is linked to non-small cell lung carcinoma.