We found that the RhB signals in the tumor tissues of RhB-PPA1-DOX group were remarkably higher than those of RhB-RAN-DOX group (Figure 5A), while the one in liver tissues of RhB-PPA1-DOX group were significant lower than those of RhB-RAN-DOX group (Figure 5A), suggesting that a tumor-specific targeting was achieved by the PPA1-DOX construct. This evidence concerns the gene RAN and neoplasm.