However, Chang and colleagues showed that PD-L1 protein level is negatively correlated with IRF7 in lung squamous cell cancer tissues, which may result from the effect of PD-1/PD-L1 reverse signaling on eIF2α/ATF4 activation with subsequent downregulation of IRF7 expression (50). The gene discussed is EIF2A; the disease is squamous cell lung carcinoma.