DNER and acute myeloid leukemia: Saenz et al. (32) used CyTOF to help evaluate the response of post-myeloproliferative neoplasm secondary AML (sAML) cells to different therapies in a xenograft model, facilitating a broad and detailed characterization of drug responses, suggesting BET protein proteolysis-targeting chimera may be more effective than bromodomain inhibitor in treating this neoplasm.