By taking the intersection as shown in Figure 4B, the expressions of CKAP2L, FAT1, GSDMC, MUC4, KRT15, KIF18B and SKA1 of 78 affected genes were up-regulated in the TCGA database, MYH11, SPTBN1, LAMC3 and CD33 were down-regulated, and other genes were not expressed differentially in lung adenocarcinoma of TCGA. The gene discussed is SPTBN1; the disease is lung adenocarcinoma.