Likewise, compared with the stress-exposed group, the percentage of time spent in open arms (F = 16.594, P < 0.001) and the percentage of open arm entries (F = 28.581, P < 0.001) in the stress+Sal group were significantly increased, suggesting that inhibition of the PERK pathway (or ER stress) may alleviate anxiety behavior. The gene discussed is EIF2AK3; the disease is Anxiety.