VPS35 and Parkinson disease: Notably, recent genetic studies, such as genome wide association study, have revealed that the chromosomal genes encoding some molecules relevant to AD-PD, including leucine rich-repeat kinase 2 (LRRK2), vacuolar protein sorting-associated protein 35 (VPS35) [34], and glucocerebrosidase (GBA), might be linked to susceptibility to sporadic PD [3], suggesting that increased αS evolvability might be associated with these AD-PD molecules.