H19 and colorectal carcinoma: For instance, Zhou et al. illustrated that lncRNA-cCSC1 modulates CSC properties in CRC through activating the Hedgehog signaling pathway, implying that lncRNA-cCSC1 might be a biomarker molecule and promising target for CRC [9]; Ren et al. corroborated that lncRNA H19 exerts as a sponge for miR-141 to facilitate the stemness and chemoresistance of CRC [10].