CD4 and hepatocellular carcinoma: Overexpression of METTL3 suppresses the expression of cytokine signaling factor 2 (SOCS2) through an m6A-YTHDF2-dependent mechanism, which in turn regulates the immunosuppression of CD4+CD25+ Foxp3Treg cells involved in TME and ultimately promotes hepatocellular carcinoma cells growth (Figure 1(e)) [64, 65].