CD8A and neoplasm: In colorectal cancer, the lack of METTL3 or METTL14 increases cytotoxic tumor-infiltrating CD8+ T cells; enhances the production of interferon- (IFN-) γ, CXCL9, and CXCL10; and promotes the recruitment of CD8+ and CD4+ effector T cells that inhibit tumor growth [74] (Figure 1(f)).