FGFR1 and neoplasm: We then established H358 cells overexpressing FGFR1 (H358-FGFR1OE), and, as expected, forced expression of FGFR1 diminished the cytotoxicity of ARS-1620, whereas combined treatment with ARS-1620 and AZD4547 enhanced the tumor cell-killing effect (Figures 1(g) and 1(h)).