PLAUR and inflammatory bowel disease: The total level of uPAR increases in patients with IBD, but the level of membrane-associated uPAR decreases as proteolysis and accumulation of the soluble form of uPAR occurs, which does not perform its functions in the activation of intracellular signaling pathways (Genua et al., 2015) This is consistent with the elevated blood level of the soluble form of uPAR in IBD (Lönnkvist et al., 2011; Kolho et al., 2012).