Only NFATC1 has a tendency to be upregulated in Caco-2 according to our RNA sequencing data: 1.6 times in dCaco-2 with OD and uCaco-2 with CoCl2, 1.9 times in dCaco-2 with CoCl2, and 2.9 times in uCaco-2 with OD, suggesting its possible role in ITGA5 and PLAUR upregulation in hypoxia and IBD. The gene discussed is ITGA5; the disease is inflammatory bowel disease.