The recent studies showed that SCGB2A1, KLF4, and PPP1R14B can differentiate a group of circa 5% of cases with less survival in chronic lymphocytic leukemia (CLL) patients, which might be useful for further research about disease prognostication and drug response in CLL (Orgueira et al., 2019). The gene discussed is KLF4; the disease is B-cell chronic lymphocytic leukemia.