Among the above five DEcircRNAs, circ-ATXN2 (circRNA-1783), which originates from the 20 exons of ATXN2 genes, has been reported to be involved in aging-related diseases, such as amyotrophic lateral sclerosis (Liu et al., 2013; Lu et al., 2015; Tavares de Andrade et al., 2018; Zhao et al., 2018; Watanabe et al., 2020; Laffita-Mesa et al., 2021), metabolism (Carmo-Silva et al., 2017), T2D, CAD, blood pressure, and inflammation (Odegaard and Chawla 2013; Kraja et al., 2014; Carmo-Silva et al., 2017), and is associated with parental longevity and longevity (Franceschi et al., 2020). This evidence concerns the gene ATXN2 and amyotrophic lateral sclerosis.