CDKN1A and breast cancer: Another report showed that the combinatorial exposures of clofarabine and EGCG or genistein synergistically inhibited the growth of breast cancer cells (MCF7 and MDA-MB-231 cells) and induces apoptosis followed by RARB hypomethylation with consequent manifold increase in RARB, CDKN1A, and PTEN transcript levels.