Interestingly, compared to moderate, certain inflammatory response–related signaling were diminished in critical, such as OSM, IL10, TWEAK, CXCL, and LIGHT, while other inflammatory response–related signaling were enhanced in critical, such as IL2, IL16, CCL, LIFR, and CD40, suggesting that different inflammatory signaling likely play distinct roles in moderate vs. critical COVID-19. The gene discussed is IL16; the disease is COVID-19.