HP and hemolysis: Frequently, but not always, there is an accompanying MAHA characterized by thrombocytopenia, a Coomb’s negative hemolytic anemia with ≥ 0.5% schistocytes on peripheral blood smear, and other laboratory evidence of intravascular hemolysis, such as elevated lactate dehydrogenase (LDH), absent haptoglobin, and increased indirect bilirubin.