Importantly, pre and post-treatment groups separated into two major clusters (“Pre/Post” bar, white vs. grey squares, Figure 3A), indicating a differential impact of HF vs. MCO dialysis, with considerable separation between patients undergoing regimen A and B (orange vs. green shows a stronger grouping/larger clustering in the group to the right), thereby identifying several molecular targets of the TNF-signaling pathway (e.g. TFN-α and sTNF-R1 and R2) to be of key importance for this separation (bottom right, red markings, Figure 3A). The gene discussed is TNF; the disease is hydrops fetalis.