TNF and hydrops fetalis: Interestingly, we found a dialysis-time dependent shift in the TNF-α/sTNF-R1-ratio in the patient serum dialyzed with MCO membranes compared to HF-dialysis (Figure 3B), which was most evident for patients undergoing the longer 12-weeks period of MCO dialysis (P<0.05 at 12-weeks and P<0.05 and P<0.01 for the comparison of pooled 4 and 12-weeks data phase 1-3 HF vs. MCO).