Based on ROC analysis, nine biomarkers (TNF-α, IL-10, MIG, IL-6, IP-10, M-CSF, G-CSF, GM-CSF, IFN-α2) were established as good early predictors for COVID-19 patients who may require ICU admission (Figures 4F, L). The gene discussed is CXCL9; the disease is COVID-19.