IL-10, which is known as a suppressor in the initiation phase of inflammation during COVID-19 and correlated strongly with proinflammatory IL-6 (r=0.5, p<0.0001) and TNF-α (r=0.6, p<0.0001), probably performing an immune-inhibitory mechanism as a negative feedback inflammation loop (29). The gene discussed is IL6; the disease is COVID-19.