In addition to the cytokines already known to be associated with disease severity in COVID-19 (IL-6, IL-10, IL-27, IL-15, G-CSF, M-CSF, IP-10, MIG, TNF-α, IL-1RA) (19, 21), which were higher in the patients in our cohort with more severe COVID-19, cytokines with significantly lower concentrations in ICU patients than in others were detected: IL-5, MDC, eotaxin, and IL-12(p40). The gene discussed is CSF3; the disease is COVID-19.