TLR3 and cancer: It is also worth noting that expression of PRRs significantly correlates to survival times in several types of cancers, such as NOD2, IFIH1, and TLR1/3/7/10 significantly positively correlate to prognosis in sarcoma (SARC); NOD1, DDX58, ZBP1, DDX60, and TLR2/3 significantly positively correlate to prognosis in mesothelioma (MESO); DDX58, AIM2, DDX60, and TLR3 significantly positively correlate to prognosis in pancreatic adenocarcinoma (PAAD).