Previous evidence, as well as our current results, indicate that under oxidative stress conditions, the CCNB1–PKD1 pair participates in IDD by regulating NP cell proliferation or apoptosis via a signaling pathway(s), such as the MAPK, nuclear factor-kappa B, and/or calcium-ion pathways. The gene discussed is PKD1; the disease is intervertebral disk degenerative disorder.