found slightly contradictory results: they observed that stimulated female and Klinefelter syndrome (KS) PBMCs had higher TLR7 and IFN-α mRNA levels than male and Turner’s syndrome female PBMCs (45, X0), supporting TLR7 XCI escape, but the KS cells did not show higher IFN-α levels after TLR7 stimulation. This evidence concerns the gene IFNA1 and Klinefelter syndrome.