IFNA1 and COVID-19: SARS-CoV-2 can obstruct IFN production: a transcriptome profiling study, which was conducted using in vitro tissue culture, ex vivo infection of primary cells and in vivo samples from COVID-19 patients and animals, found that SARS-CoV-2 yields lower levels of type 1 IFN, a lower response of ISGs, and high levels of chemokines, in comparison to other respiratory viruses.