RNA sequencing and genome-wide genotyping of monocyte-derived macrophages from patients with system sclerosis revealed that the GSDMA rs3894194 risk variant contributed to several inflammatory pathways and system sclerosis susceptibility, characterized by upregulation of glycolysis, hypoxia, and mTOR signaling and downregulation of the IFN-γ response pathway (137). Here, GSDMA is linked to systemic sclerosis.