GSDMB-regulated genes, cytokines, and chemokines, such as TGF-β1, MMP-9, 5-LO, cysteinyl leukotrienes (LTC4/D4/E4), HSP60/70, and CXCLs, contribute significantly to airway inflammation and remodeling in asthma (2). Here, GSDMB is linked to asthma.