Animal death caused by sepsis in response to intravenous injection of PAMP from E. coli was attenuated in mice with Casp1, Casp1/11, and Gsdmd depletion but not in Tlr4–/–, Casp11–/– mice or mice lacking receptors for IL-1B (Il1r–/–) and IL-18 (Il18r–/–). This evidence concerns the gene CASP1 and Sepsis.