ITGB2 and Increased total leukocyte count: LAD1 is associated with mutations in ITGB2, which is the gene for the beta chain of beta-2 integrins, also known as CD18, and mediates cell-cell and cell-extracellular matrix adhesion (294, 295).Therefore, LAD1 patients present leukocytosis with neutrophilia associated with recurrent bacterial infections and impaired pus formation and wound healing (296).