CD8A and hemophagocytic syndrome: Hemophagocytic lymphohistiocytosis (HLH) is a life‐threatening hyperinflammatory disease mainly in children younger than 1 year manifested by high persistent fever, pancytopenia, hepatosplenomegaly, and elevated aminotransferase and ferritin levels (258).The cytotoxic activity of CD8+ T cells and natural killer (NK) cells is impaired in primary HLH, impeding the elimination of virus‐infected cells and instead causing continuous secretion of inflammatory cytokines, especially soluble CD25.