All metabolites had significant positive association with BMI, whereas only MEOHP showed a significant association with WC after the adjustment.Most of the phthalates were associated with obesity (T3 vs T1) [MBP: OR=1.26 (0.54, 1.98)], [MBzP: OR=5.54 (4.79, 6.28)], [MMP: OR=4.26 (3.56, 4.96)], [MEHP: OR=3.63 (2.95, 4.31)], and [MEHHP: OR=4.16 (3.31, 5.01)]. The gene discussed is MBP; the disease is Obesity.