Patients with glomerulonephritis class IV showed significantly higher urinary levels of five mRNAs (nicotinamide N-methyltransferase [NNMT], thrombospondin 2 [THBS2], collagen type III alpha 1 chain [COL3A1], spondin 2 [SPON2], and collagen type I alpha 1 chain [COL1A1]), compared with those exhibiting glomerulonephritis class II (Figure 3A). Here, SPON2 is linked to glomerulonephritis.