INS and type 2 diabetes mellitus: For instance, Marcus et al. (2013) showed that despite 16-weeks of RT in patients with T2DM, which promoted an improvement in SMM (∆ 8%) and regional insulin sensitivity based on a euglycemic-hyperinsulinemic clamp (∆ 33.9%), there was a loss in whole-body insulin sensitivity (∆ –12.4%) 7days after exercise csessation even though SMM was maintained.