NLRP3 and diabetic kidney disease: NLRP3, caspase1, and ASC are pyroptosis-related genes and Kcnq1ot1 knockdown reverses the high level of NLRP3 in diabetic nephropathy, inhibits caspase1 in cardiomyocytes (Yang et al., 2018b; Zhu et al., 2020).