Level 1 confirmation. Hepatic lipase (HL) is an enzyme that hydrolysis triglycerides and has a putative role in the catabolism of HDL particles (Connelly, 1999). HL can either remain attached to the liver or is in free form in blood. HL deficiency causes hepatic inflammation in mice (Andrés-Blasco et al., 2015), the potential effect in humans needs to be studied. The gene discussed is LIPC; the disease is inflammatory response.