SERPINA3 and type 2 diabetes mellitus: Level 3 confirmation. Alpha-1-antichymotrypsin (AACT) is an acute phase protein synthesized in liver and induced during inflammation. Plasma levels of AACT are reduced with NASH (Hou et al., 2020) and with prediabetes, type 2 diabetes and abdominal obesity compared to normal (Kim et al., 2019).