Level 2 confirmation. IGFBP2 protein levels are altered in type 2 diabetes mellitus patients and associated with cardiovascular disease risk factors. IGFBP2 concentration is lower in T2D patients vs healthy controls; inversely associated with pulse wave velocity in T2D and healthy controls (Hjortebjerg et al., 2017). This evidence concerns the gene IGFBP2 and type 2 diabetes mellitus.