TNF and metabolic dysfunction-associated steatohepatitis: Despite these differences in metabolism between mice and humans, we have shown previously that the key molecular inflammatory responses in obese Ldlr−/−.Leiden mice and humans are similar (Morrison et al., 2018): the hepatic inflammatory response in NASH patients (non-alcohol steatohepatitis; due to an increased metabolic load) has large similarities to the obese Ldlr−/−.Leiden mice fed with a HFD demonstrated by the activation of the majority of identical inflammatory processes and master regulators (e.g., TNF, CSF2, TGFB1) (Morrison et al., 2018).