KRT18 and fatty liver disease: Level 2 confirmation. Keratin 18 is expressed in epithelial tissue. Circulating levels of keratin 18 predict drug induced liver injury (Llewellyn et al., 2021), act as diagnostic and prognostic biomarker for acute alcoholic hepatitis (Vatsalya et al., 2020), and are associated with hepatic steatosis in elderly T2D patients (Morling et al., 2014). Keratin 18 had weak positive associations with several metabolic risk factors (glucose, HbA1c, BMI, waist, triglycerides) in elderly T2D patients (Morling et al., 2014).