Level 3 confirmation Resistin is an adipokine that is secreted by adipose tissue and stimulating expression of pro-inflammatory cytokines. Although there is some discussion, there is increasing consensus on the positive association between resistin and obesity, insulin resistance, and cardiovascular disease (Su et al., 2019; Recinella et al., 2020). The gene discussed is RETN; the disease is obesity due to melanocortin 4 receptor deficiency.