Suggesting a suppressive role of TRESK over trigeminal ganglia excitability, KCNK18 knockout mice reportedly exhibit mechanical and thermal hyperalgesia in response to systemic glyceryl trinitrate treatment (a migraine model) (Pettingill et al., 2019) and exaggerated nocifensive behaviors in response to dural application of inflammatory soup (Guo et al., 2019). Here, KCNK18 is linked to migraine disorder.