CA2 and mood disorder: The Ca+2 channel blocking properties of mood stabilizer drugs, lithium, valproic acid, carbamazepine and lamotrigine as well as efficacy of verapamil, a Ca+2 channel blocker as a mood stabilizing agent support the role of Ca+2 in the pathophysiology of mood disorders and point to the promising potential of BBB-permeable Ca+2 channel blockers in the treatment of mood disordes (for detailed reviews please see (Cipriani et al., 2016; Dubovsky, 2019; Harrison et al., 2020).