F139Wfsx24 KCNK18 frame-shift mutation has been shown to result in hyperexcitability of cultured trigeminal ganglion neurons as well as allodynia in rodent migraine models (isosorbide dinitrate injection) by a negative dominant effect on TREK1 and 2, two other two-pore-domain potassium channels with which TRESK channels form functional heterodimers (Liu et al., 2013; Royal et al., 2019). The gene discussed is KCNK18; the disease is migraine disorder.