CACNA1C and migraine disorder: Voltage-gated calcium channels and two-pore domain K+ channels, the role of which are discussed in the context of migraine in the previous section are also involved in the pathophysiology of mood disorders: Genetic variations in CACNA1C gene, which encodes for the alpha subunit of L-type calcium channels (Cav1.2) as well as CACNA1E, which encodes for the alpha 1E subunit of R-type calcium channel (CaV2.3 channel) were reported in mood disorders (Ferreira et al., 2008; Psychiatric, 2011; Nurnberger et al., 2014; Howard et al., 2019).