CREB1 and melanoma: SP has been reported to have anti-inflammatory effect (Chaingam et al., 2020) and antioxidant effect (Usman et al., 2020), When B16F10 melanoma cells were treated with 0–50 μm SP, it was found that SP to induce melanin synthesis in a dose-dependent manner by increasing the expression of MITF and tyrosinase via increasing CREB phosphorylation (Ahn et al., 2014).