HMOX1 and vitiligo: In human vitiligo melanocytes (PIG3V) induced by hydrogen peroxide, baicalein increased the expression of Nrf2 and its downstream gene HO-1 in PIG3V cells, promoted the translocation of Nrf2 from cytoplasm to nucleus, indicating that the protective effect of baicalein on melanocytes depends on Nrf2 signaling pathway (Ma et al., 2018).