Moreover, downstream from the striatum (Figure 1C), selective optogenetic activation of GPe GABAergic interneurons or GPe-projecting STN afferents produces hyperkinesia and abnormal involuntary movements in mice, such as abnormal forelimb posture, neck’s torsion spasm, and compulsive grooming, chewing and licking (Tian et al., 2018). This evidence concerns the gene GYPE and Hyperkinetic movements.