A systematic review suggested that some factors of the hemostatic system, for example vWF, FXI, prothrombin fragment 1 + 2 (F1.2), D-dimer, plasminogen activator inhibitor 1 (PAI-1) and anti-phosphatidyl serine antibodies (aPS), are related to poor clinical outcome after ischemic stroke. This evidence concerns the gene SERPINE1 and ischemic stroke.