TSC1 and tuberous sclerosis: Other syndromic ASD conditions including Tuberous Sclerosis (TSC1/2; Wiznitzer, 2004; Mills et al., 2017), Fragile X syndrome (FMR1; Luo et al., 2010) and Rett Syndrome (MECP2; Hsu et al., 2020) have also shown abnormal activation of Wnt signaling mediated transcription.