The expression levels of transferrin and BAX were significantly increased by 1.9− and 2.7-fold (p < 0.05 and p < 0.001), respectively, in the Tg group compared with the nTg group, while treatment with HE in the Tg-HE group dramatically reduced their expression levels each by 1.8-fold (p < 0.05 and p < 0.01) compared with those in the Tg group. The gene discussed is BAX; the disease is hereditary elliptocytosis.