SNAI1 and colorectal carcinoma: By analyzing the global transcriptomic changes during SNAIL1-induced EMT in SMAD4mut cells, we establish their similarity to multiple published EMT core gene signatures [20, 22–24] and to the gene expression profile of consensus molecular subtype 4 (CMS4) of human CRC, which is characterized by a mesenchymal phenotype and highly unfavorable prognosis [25].