FLT3 and acute myeloid leukemia: Additional multivariate Cox regression analysis including age, WBC count, FLT3-ITD and NPM1 mutation status (mutated vs wild-type), as well as TERT rs2853669 (CC vs CT + TT) homozygosity showed that CC genotype was also associated with overall survival in AML patients (HR 8.066, p = 0.0230).