At a significance level corrected for multiple testing we identified 2 class II HLA alleles (HLA-DQB1-0201 and HLA-DRB1-0301) associated with increased risk for SS (P < 3 × 10–07) which also are associated with the Anti-La/SSA presence (P < 2 × 10–04) and with the IFN epigenetic signature (P < 1 × 10–04) measured as the decreased in DNAm at IFN-related genes (Table 1). Here, TRIM21 is linked to synovial sarcoma.