ALB and synovial sarcoma: On the other hand, those genes showing DMRs with positive effects were found to be enriched in pathways such as Collagen biosynthesis and modifying enzymes (Reactome, R-HSA-1650814) and extracellular matrix organization (Reactome R-HSA-1474244) (Fig. 2, Supplementary Table 6), which represent novel molecular pathways implicated in SS, and might indicate that the hypermethylation of these genes can be implicated in SS pathogenesis by down-regulating these molecules.