The top ORAI2 RNA editing event (chr7: 102096952) is therefore associated with multiple traits (Fig. 6d, e and Table S5), including AD dementia (P = 4.8 × 10−7) and PHFtau accumulation (P = 4.72 × 10−8); it is also close to genome-wide significance with cognitive decline (P = 3.07 × 10−6) and has a more modest association with β-amyloid (P = 7.31 × 10−4). The gene discussed is ORAI2; the disease is Mental deterioration.