Focusing on the RNA editing component explored in this manuscript, two of the editing events associated with AD dementia stand out: (1) the edited site in the 3′-UTR of SYT11 which appears to influence SYT11 protein level, and (2) the ORAI2 3′-UTR editing event which is associated with multiple diagnostic and intermediate traits, allowing us to propose where, in the causal chain of events leading to AD, RNA editing may have an effect for this gene. Here, ORAI2 is linked to Alzheimer disease.