We also identified 7 AD-associated RNA editing events that meet a rigorous threshold of transcriptome-wide significance, and we elaborate the role of two of them: (1) ORAI2 in the accumulation of Tau pathology that contributes to the cascade of events leading to AD and (2) SYT11 in potential synaptic disruption from the decreased protein levels that may contribute to AD dementia. The gene discussed is ORAI2; the disease is Alzheimer disease.