A comparative study of the tumor markers between the sgPten+sgp53 indel cynomolgus monkeys and the sgCherry or PBS group following the CRISPR/Cas9 injection revealed that serum levels of AFP, CA125, and CA19-9 were significantly increased in the sgPten+sgp53 indel monkeys compared with the sgCherry or PBS group. Here, MUC16 is linked to neoplasm.