SFRP2 and periodontitis: Consistent with our in vivo ossicle results, Sfrp2 overexpression in stem cells from the apical papilla (SCAPs) exhibited a superior tissue regeneration capacity in a periodontitis/regeneration model in miniature pigs,53 and subcutaneous transplantation of Sfrp2 knockdown SCAPs (SCAPs of teeth) demonstrated less dentin-like tissue formation than normal cells.54