The proportion of PTV carriers in four genes were significantly different between Chinese and Malay breast cancer patients (Fisher’s exact test, BRCA1, p = 0.009; BRCA2, p = 0.008; MUTYH, p = 2.65E−4; MSH6, p = 0.003, Additional file 1: Table S4). The gene discussed is MSH6; the disease is breast carcinoma.