BRCA1 and neoplasm: Two smaller studies on Asian Chinese breast cancer patients showed that while BRCA1/2 PTV carriers were associated with more aggressive clinical features, PTV carriers of non-BRCA1/2 breast cancer susceptibility genes when treated as a single group were not significantly associated with tumor characteristics (Wang et al., 480 patients, 65 PTV carriers for 20 genes [23]; Li et al., 936 patients, 223 PTV carriers for 40 genes [22]).