PHF19 and chronic myelogenous leukemia, BCR-ABL1 positive: In the human CML cell line model, K562, that could be differentiated toward erythroid or megakaryocyte cell fate, PHF19 depletion enhanced erythroid differentiation while impeding megakaryocyte cell fate induction [50] suggesting that PHF19 might be important for lineage differentiation from bipotent megakaryocyte-erythrocyte progenitors.