Connected with this, in rheumatoid arthritis, a chronic and systemic autoimmune disease affecting both joints and extra-articular tissues, and in which germinal center and autoantibodies play an important role, PHF19 expression was shown to be higher in lymphocytes from synovial fluid and peripheral blood of rheumatoid arthritis patients compared to healthy controls [76]. The gene discussed is PHF19; the disease is rheumatoid arthritis.