NSD2 and Miyoshi myopathy: However, t(4;14) MM cells exhibit enhanced recruitment of EZH2 and enrichment of H3K27me3 at specific genomic loci involved in normal germinal center B-cells differentiation and in a subset of c-MYC targets genes in B-cells suggesting that EZH2-mediated repression of these genes may be important for NSD2-induced oncogenesis [97].