Using an shRNA loss-of-function approach, several study have shown that MM cell lines with different genetic background (ARP1, OCI-My5, JJN3, MM1S, L363, RPMI8226, H929 and KMS11) are dependent on PHF19 for their proliferation [15, 16, 52, 103]; however, the mechanism by which this is mediated remains undefined. Here, PHF19 is linked to Miyoshi myopathy.