Specifically, in GC B-cells the expression of PHF19 peaks in the G2-M phase of the cell cycle and this is followed by the modulation of several genes of the PHF19 transcriptional signature that we identified in MM and that are involved in cell cycle regulation including PLK4, BUB1, CENPE, NUF2 and AURKB (Fig. 6B). Here, AURKB is linked to Miyoshi myopathy.