AKT1 and Miyoshi myopathy: In contrast, Yu et al. [52] reported that PHF19 depletion promotes the phosphorylation of EZH2 leading to EZH2 inactivation via the PI3K/AKT pathway, thus causing a decrease in H3K27me3 and H3K27me2 marks thus promoting the expression of genes involved in MM cell survival, proliferation and conferring drug resistance via JUN, KLF, RELB, HIF1α, BCLXL and MCL1.