Using Toolkit for Cistrome Data Browser [23, 24] that calculates a regulatory potential (RP) score for a given gene using TF ChIP-seq samples from cancer and normal cells, we show that the top 20 TFs and chromatin regulators that regulate PHF19 expression in a region up to 10 kilobase from the TSS include RUNX1, FLI1, SPI1, MYC, E2F1, CTCF, HDAC2, TET2 and EZH2 (Fig. 1B). The gene discussed is EZH2; the disease is cancer.