In contrast, Yu et al. [52] reported that PHF19 depletion promotes the phosphorylation of EZH2 leading to EZH2 inactivation via the PI3K/AKT pathway, thus causing a decrease in H3K27me3 and H3K27me2 marks thus promoting the expression of genes involved in MM cell survival, proliferation and conferring drug resistance via JUN, KLF, RELB, HIF1α, BCLXL and MCL1. This evidence concerns the gene EZH2 and Miyoshi myopathy.