TPM1 and familial dilated cardiomyopathy: The Myosin head domain from the gene MYO19 interacts with 6 other genes associated with DCM: (1) MYL2, which triggers contraction after Ca+ activation [89]; (2–5) TPM1/TPM2/TPM3/TPM4, which encode the TPM protein—the main regulator of muscle contraction [90]; and (6) ACTG, which encodes actin.