TLR10 and myeloid sarcoma: In line with the neurodegenerative and immune-mediated features of MS, NEASE found unique enriched pathways related to brain network signaling and neuronal pathways “Neurotransmitter receptors and postsynaptic signal transmission,” “Transmission across Chemical Synapses,” “Activation of NMDA receptor and postsynaptic events,” “MAPK family signaling cascades,” “Neuronal System”), as well as pathways related to immune responses (“interleukin-17 signaling,” “Toll-Like Receptor 10 (TLF10) Cascade”) (Table 1 and Additional file 5: Table S20).