HIF1A and neoplasm: Among them, the PI3K/AKT and MAPK signaling pathways are closely related to the proliferation and metastasis of tumor cells, FoxO and HIF-1 signaling pathways can interfere with the tumor hypoxic microenvironment, and the MicroRNAs signaling pathway can regulate the EMT process of tumor cells and intervene in the process of tumor cell metastasis.