At the same time, hypoxia can induce MiR-153 to fine-tune HIF1α/VEGFA in breast cancer angiogenesis [97], MiR-100 can inhibit in vitro angiogenesis by regulating the mTOR/HIF-1α/VEGF signal transduction axis in breast cancer cells [98]. The gene discussed is MTOR; the disease is breast carcinoma.