Intriguingly, Pladienolide-B did not influence the expression of genes relevant to tumor biology (apoptosis, proliferation, inflammation) in MIAPaCa-2 cells or in HPDE E6E7 cells, including NFKB1, CASP3, MKI67, and HER2 (Fig. 4B). The gene discussed is MKI67; the disease is neoplasm.