Embryos injected with pre-treated MIAPaCa-2-mCherry-H2B cells showed a marked reduction in cell dissemination at 4-dpi, while those injected with pre-treated A6L-mCherry-H2B PDX-derived cells showed a drastic reduction in tumor cell dissemination and growth at 4-dpi, which was further enhanced at-6 dpi (Fig. 7A, B; representative images, 7C). The gene discussed is H2BC21; the disease is neoplasm.