KEGG analysis of the genes differentially spliced, depending on SF3B1 expression, revealed a particularly tight association with the “pancreatic cancer” category (the term with the highest gene ratio i.e., number of hits divided by the total genes of that KEGG term), but also with colorectal cancer and relevant signaling pathways in cancer (Fig. 2D). Here, SF3B1 is linked to familial pancreatic carcinoma.