The Splicing Factor 3B Subunit 1 (SF3B1) is a spliceosome component essential in pre-RNA processing and the most frequently mutated splicing factor across cancers, particularly in hematological malignancies but also in solid tumors, including PDAC (although at a much lower frequency, 4% of cases) [3, 4, 12] (reviewed in [7, 13, 14]). The gene discussed is SF3B1; the disease is cancer.