SF3B1 and neoplasm: Towards this end, we assessed SF3B1 expression in human tumor samples and in RNA-seq datasets, examined the molecular associations of SF3B1 with splicing and mutational features by biocomputational approaches, and tested the functional consequences of modulating SF3B1 with Pladienolide-B in both PDAC cell line models and cell lines enriched in CSCs established from PDAC patient-derived xenografts (PDX).