Several lines of evidence have implicated the endo-β-D-glycosidase heparanase encoded by the HPSE gene (HGNC ID 5164) and its substrates, i.e. the heparan sulfate (HS) chains of HS proteoglycans (HSPGs), in critical processes of the pathobiology of several tumor types including sarcomas (e.g. growth, angiogenesis, inflammation, metastasis, drug resistance) [27–32]. Here, HPSE is linked to neoplasm.